Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.863


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX1chr10_+_1028810500.655.9e-03Click!
TLX3chr5_+_170668892-0.312.3e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_40093245 3.763 NM_001145398
TEF
thyrotrophic embryonic factor
chr1_-_16217025 3.076 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr11_+_1200868 2.662 NM_002458
MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr17_+_24394043 2.168 NM_016518
PIPOX
pipecolic acid oxidase
chr22_+_21065202 2.166


chr6_-_31853027 2.148 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr1_+_183970093 2.094 NM_031935
HMCN1
hemicentin 1
chr22_+_21065134 2.038 LOC100290481
immunoglobulin lambda light chain-like
chr1_-_218168548 1.963 NM_018713
SLC30A10
solute carrier family 30, member 10
chr22_+_21065207 1.953 IGLJ3
immunoglobulin lambda joining 3
chr6_-_30151526 1.947 NM_170769
NM_025236
RNF39

ring finger protein 39

chr2_-_217268492 1.886 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr17_-_74487527 1.759 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr17_+_24394281 1.744 PIPOX
pipecolic acid oxidase
chr17_-_43254117 1.720 OSBPL7
oxysterol binding protein-like 7
chr11_+_59279481 1.677 STX3
syntaxin 3
chr19_+_15644885 1.644 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_218168404 1.642


chr17_-_43254132 1.625 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr11_-_64520964 1.601 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr6_+_132170847 1.573 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_-_192420168 1.551 NM_004657
SDPR
serum deprivation response
chr3_+_38007264 1.508 VILL
villin-like
chr7_-_100077072 1.485 NM_003227
TFR2
transferrin receptor 2
chr1_-_23568854 1.476 NM_001077195
ZNF436
zinc finger protein 436
chr6_-_3390197 1.476 NM_021945
SLC22A23
solute carrier family 22, member 23
chr14_+_22581215 1.475 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr11_+_1200894 1.455 MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr2_+_128009782 1.438 NM_001080527
MYO7B
myosin VIIB
chr17_+_21249040 1.412 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr6_+_132170888 1.411 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr19_+_3659358 1.384 TJP3
tight junction protein 3 (zona occludens 3)
chr1_-_151866593 1.338 NM_001024211
S100A13
S100 calcium binding protein A13
chr22_-_22970850 1.314 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr7_-_143587653 1.306 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr2_-_192419896 1.272 SDPR
serum deprivation response
chr8_-_145672525 1.263 NM_003923
FOXH1
forkhead box H1
chr7_-_99411573 1.220 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_-_39910296 1.194 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr1_-_151867338 1.187 NM_005979
S100A13
S100 calcium binding protein A13
chr17_+_75507750 1.146


chr11_+_1848674 1.138 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chr22_+_21116283 1.134


chr19_+_50004134 1.109 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr9_+_123083540 1.108 GSN
gelsolin
chr1_+_151867483 1.077 NM_006271
S100A1
S100 calcium binding protein A1
chr8_+_144366442 1.052 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr1_-_27113018 1.045 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr20_+_43468046 1.037 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr11_-_65082208 1.029 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr1_-_115102106 1.018 CSDE1
cold shock domain containing E1, RNA-binding
chr16_-_30032330 1.005 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_115102109 1.002 CSDE1
cold shock domain containing E1, RNA-binding
chr19_+_15612706 0.991 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr10_-_50916526 0.974 NM_001077686
AGAP4
AGAP8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr12_+_56406296 0.974 LOC100130776
hypothetical LOC100130776
chr19_+_40322231 0.974 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_65082705 0.955 LTBP3
latent transforming growth factor beta binding protein 3
chr16_-_49742651 0.937 NM_002968
SALL1
sal-like 1 (Drosophila)
chr17_-_4410565 0.934 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr16_+_56219802 0.918 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr22_-_29866339 0.917 NM_015715
PLA2G3
phospholipase A2, group III
chr2_+_66516196 0.917 MEIS1
Meis homeobox 1
chr20_+_43952997 0.915 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr1_-_115102124 0.906 CSDE1
cold shock domain containing E1, RNA-binding
chr1_-_115102084 0.876 CSDE1
cold shock domain containing E1, RNA-binding
chr1_-_115102138 0.873 NM_001007553
NM_007158
NM_001130523
CSDE1


cold shock domain containing E1, RNA-binding


chr22_+_21053972 0.833


chr15_-_63290839 0.827 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_-_32054164 0.818 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_159435728 0.818 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr17_+_71065478 0.802 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr17_-_44226595 0.775 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr20_+_55569542 0.768 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr14_+_19365447 0.768 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr14_-_22515725 0.765 JUB
jub, ajuba homolog (Xenopus laevis)
chr16_+_55963899 0.758 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr20_-_31495086 0.752 NM_003098
SNTA1
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
chr1_-_245342150 0.749 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr11_+_6216905 0.745 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr19_+_54068373 0.742 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr8_-_27525084 0.728 NM_001171138
CLU
clusterin
chr1_+_61319976 0.720 NM_001145512
NFIA
nuclear factor I/A
chr20_+_34206070 0.714 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr2_-_233586164 0.707 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr8_-_17148474 0.695 CNOT7
CCR4-NOT transcription complex, subunit 7
chr3_-_140879463 0.694 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr2_-_233586145 0.686 NGEF
neuronal guanine nucleotide exchange factor
chr8_-_143864933 0.684 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr5_+_150000394 0.675 NM_001109974
NM_007286
SYNPO

synaptopodin

chr16_-_19803606 0.674 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr6_+_35373572 0.663 NM_022047
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr3_-_50315983 0.663 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr19_+_54068300 0.662 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr10_-_51156329 0.661 NM_001077685
AGAP4
AGAP7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
chr20_-_43953036 0.654 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr1_-_171286634 0.652 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr1_-_151866367 0.645 NM_001024212
S100A13
S100 calcium binding protein A13
chr19_-_8581559 0.644 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr7_+_128142661 0.641 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr8_-_27524744 0.641 NM_203339
CLU
clusterin
chr16_-_2037819 0.640 NM_002528
NTHL1
nth endonuclease III-like 1 (E. coli)
chr7_-_150283794 0.637 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr4_-_977163 0.624 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr2_+_223244606 0.621 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr5_-_145232723 0.619 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr20_-_33489383 0.616 NM_000557
GDF5
growth differentiation factor 5
chr16_-_2204776 0.615 NM_001042371
PGP
phosphoglycolate phosphatase
chr5_+_176744037 0.612 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr9_-_138387903 0.611 CARD9
caspase recruitment domain family, member 9
chr12_-_27126721 0.605 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr1_-_199259133 0.604 KIF21B
kinesin family member 21B
chrX_-_54841397 0.603 NM_198510
ITIH5L
inter-alpha (globulin) inhibitor H5-like
chr1_+_54132447 0.601 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr11_+_119616112 0.598 NM_014352
POU2F3
POU class 2 homeobox 3
chr17_+_58915909 0.594 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr2_+_185171337 0.591 NM_194250
ZNF804A
zinc finger protein 804A
chr19_-_40696393 0.587 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chrX_-_110541029 0.586 NM_000555
DCX
doublecortin
chr2_+_24869753 0.584 NM_024322
CENPO
centromere protein O
chr6_-_638010 0.583 NM_018303
EXOC2
exocyst complex component 2
chr3_+_8750485 0.582 NM_033337
NM_001234
CAV3

caveolin 3

chr10_-_45662912 0.581 NM_133446
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr17_-_39700960 0.579 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr15_-_87840780 0.578 NM_016321
RHCG
Rh family, C glycoprotein
chr8_-_17148637 0.575 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr2_+_66516020 0.563 NM_002398
MEIS1
Meis homeobox 1
chr10_-_69267774 0.561 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr3_+_9766994 0.561 OGG1
8-oxoguanine DNA glycosylase
chr14_+_94117545 0.551 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_+_9766901 0.550 OGG1
8-oxoguanine DNA glycosylase
chr6_+_34312979 0.549 HMGA1
high mobility group AT-hook 1
chr6_-_38778860 0.548 GLO1
glyoxalase I
chr2_+_218896219 0.546 PNKD
paroxysmal nonkinesigenic dyskinesia
chr9_-_8723893 0.545 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_-_42507180 0.538


chr2_-_74588293 0.533 NM_032673
PCGF1
polycomb group ring finger 1
chr1_+_16247870 0.532 NM_001165945
CLCNKB
chloride channel Kb
chr5_+_176726918 0.531 RGS14
regulator of G-protein signaling 14
chr2_-_24869718 0.531 NM_001013663
C2orf79
chromosome 2 open reading frame 79
chr10_+_94823636 0.530 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_-_120781002 0.529 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr6_-_43703024 0.527 GTPBP2
GTP binding protein 2
chr1_+_199259664 0.526


chr11_+_74548472 0.524 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_-_199259447 0.523 NM_017596
KIF21B
kinesin family member 21B
chr14_+_20595820 0.520 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr11_-_118716736 0.513 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr10_+_685887 0.508 C10orf108
chromosome 10 open reading frame 108
chr11_-_62213577 0.506 LRRN4CL
LRRN4 C-terminal like
chr7_+_115952325 0.504 CAV1
caveolin 1, caveolae protein, 22kDa
chr9_-_123301856 0.502 GGTA1
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr11_+_116205830 0.502 NM_000040
APOC3
apolipoprotein C-III
chr10_-_126097444 0.501 OAT
ornithine aminotransferase
chr3_+_9766602 0.500 NM_002542
NM_016819
NM_016820
NM_016821
NM_016826
NM_016827
NM_016828
NM_016829
OGG1







8-oxoguanine DNA glycosylase







chr9_+_130056513 0.497


chr20_-_33580861 0.496 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr3_-_31997738 0.492 OSBPL10
oxysterol binding protein-like 10
chr22_+_20252015 0.489 UBE2L3
ubiquitin-conjugating enzyme E2L 3
chr2_-_74588006 0.488 PCGF1
polycomb group ring finger 1
chr7_+_6760264 0.483 NM_173565
NM_001099697
RSPH10B
RSPH10B2
radial spoke head 10 homolog B (Chlamydomonas)
radial spoke head 10 homolog B2 (Chlamydomonas)
chr2_+_97696462 0.480 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr8_-_145097031 0.479 NM_201380
PLEC
plectin
chr7_+_115952279 0.477 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr10_-_126097483 0.475 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr6_+_32057779 0.474 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr1_+_54786394 0.473 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr1_-_32940850 0.473 SYNC
syncoilin, intermediate filament protein
chr7_-_36991189 0.472 NM_001039459
ELMO1
engulfment and cell motility 1
chr1_-_159459814 0.470 APOA2
apolipoprotein A-II
chr1_-_23683214 0.469 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr5_-_36277441 0.468 C5orf33
chromosome 5 open reading frame 33
chr22_-_37970902 0.467 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr1_-_159435440 0.464 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr1_-_159459999 0.462 NM_001643
APOA2
apolipoprotein A-II
chr3_-_53855443 0.457 NM_018397
CHDH
choline dehydrogenase
chr20_-_60375695 0.456 NM_005560
LAMA5
laminin, alpha 5
chr6_-_38778893 0.455 GLO1
glyoxalase I
chr22_+_19239221 0.452 MED15
mediator complex subunit 15
chr2_+_185171537 0.451 ZNF804A
zinc finger protein 804A
chr6_-_43703057 0.450 GTPBP2
GTP binding protein 2
chr3_-_58538110 0.448 FAM107A
family with sequence similarity 107, member A
chr14_+_23675233 0.444 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_-_71995401 0.441 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr1_+_23994914 0.439


chr3_+_63928459 0.438 NM_001128149
ATXN7
ataxin 7
chr9_-_137731139 0.438 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr9_+_135389698 0.437 NM_014694
ADAMTSL2
ADAMTS-like 2
chr6_-_38778882 0.436 GLO1
glyoxalase I
chr22_+_21870293 0.435


chr5_-_36277656 0.433 NM_001085411
C5orf33
chromosome 5 open reading frame 33
chr5_+_176449156 0.432 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr16_+_65783571 0.432 E2F4
E2F transcription factor 4, p107/p130-binding
chr7_+_50318801 0.431 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr9_+_130719034 0.429 LRRC8A
leucine rich repeat containing 8 family, member A
chr6_-_38778898 0.428 GLO1
glyoxalase I
chr11_-_85074848 0.426 NM_152723
CCDC89
coiled-coil domain containing 89
chr2_-_218551786 0.423 TNS1
tensin 1
chr1_-_229181203 0.422 TTC13
tetratricopeptide repeat domain 13
chr10_-_49993425 0.422 NM_001031746
NM_144984
C10orf72

chromosome 10 open reading frame 72


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 1.80e-03 GO:0005576 extracellular region
1.60 2.36e-03 GO:0044421 extracellular region part
1.89 3.42e-02 GO:0031012 extracellular matrix

Nothing significant found in function category.